During sleep, your body enters rapid eye movement or REM sleep, which lasts from few minutes to a half hour. During these REM periods, men experience several erections and women experience vaginal lubrication. If a dream during REM sleep is very arousing, the sensation of an erect penis pressed against a mattress can lead to erotic dreaming and ejaculation in men.
People who have nocturnal emission have to change the sheets frequently. They get annoyed and want to prevent wet dreams. Nevertheless, true remissions occur, and further studies are needed to understand the immunological background of this phenomenon and to obtain a better understanding of the natural history of the disease. Paroxysmal nocturnal hemoglobinuria PNH is an acquired syndrome characterized by intravascular hemolysis, thrombosis, and bone marrow BM failure 1.
The disease is caused by a mutation in the PIG-A gene that leads to the lack of glycosylphosphatidylinositol GPI -anchored molecules, including the complement regulatory proteins CD55 and CD59 from the surface of a clonal lineage of blood cells 2 — 4. In addition, rare forms of PNH with mutations in the CD59 gene have been described indicating the key role of the absence of CD59 in the disease 5 , 6.
The diagnosis of PNH is made by analyzing GPI-anchored molecules or the anchor itself on blood cells by flow cytometry. The disease course is often unpredictable, and the therapeutic options are limited. Recently, four cases of spontaneous remission were described in two different studies 9 , 10 , but doubts exist whether remissions really occur in PNH patients. In particular, it would be important to distinguish true remissions from other developing disorders, especially from malignancy, because in both cases the PNH diagnostics may give a negative result.
Because of the variable clinical course of PNH, we wanted to explore whether true spontaneous remissions occur in PNH in the Finnish patient material that we have collected during a long period of time. A nation-wide study of all PNH patients diagnosed in Finland since and an extended follow-up time up to 20 years have provided a unique opportunity to perform a detailed analysis of the course of the disease in our patients.
In a nation-wide project, we collected patients from all Health Care Districts in Finland with a total population of 5. The patients were evaluated until September , and the remission cases were followed until June In total, patients with a CDdeficient cell clone in flow cytometry were included in the study. Besides the flow cytometry analysis the laboratory parameters included levels of hemoglobin Hb , lactate dehydrogenase, haptoglobin, erythrocytes, leukocytes, platelets, inflammation markers CRP, ESR , D-dimer, fibrinogen, coagulation factor VIII, creatinine, and ventricular natriuretic peptide.
In addition, the glomerular filtration rates and BM analyses were performed. The clinical data included the symptoms and conditions attributable to PNH: hemoglobinuria, thrombotic events, infections, fatigue, renal failure, pulmonary hypertension, abdominal pain, dysphagia, dyspnea, erectile dysfunction, anemia, and the co-existence of PNH with aplastic anemia AA , myelodysplastic syndrome MDS , or leukemia. An ethical permission for the study was provided by the coordinating ethical committee at the Helsinki University Hospital Health Care District.
A research permission was also obtained from the National Institute of Health and Welfare THL, Helsinki, Finland , and the patients gave written informed consents for the study.
In a cohort of Finnish patients with a PNH clone, we found 6 cases, where the clone disappeared or clearly diminished to a level equal or below 1. Two of the six patients subsequently developed leukemia acute myeloid leukemia and chronic myelomonocytic leukemia , while the other four are in clinical remission Table 1. Patient number 1 was diagnosed with AA in during a twin pregnancy.
The patient had pre-eclampsia and a cesarean section was performed. The patient was first treated with steroids without any positive outcome and with androgens for 2 years. In , the patient was diagnosed with multiple sclerosis.
In the mid 90s, the patient got several blood transfusions and twice more in and No thrombotic complications occurred. The patient was given anticoagulation treatment.
Keep scrolling for more. Examples of nocturnal in a Sentence he bought a new telescope so he could pursue his favorite nocturnal hobby of astronomy. Recent Examples on the Web Mammals evolved as nocturnal beings that did not need to see the rich hues of the daylight world, so most—like your pet dog and cat—are dichromatic, and have only blue and green cones.
First Known Use of nocturnal 15th century, in the meaning defined at sense 1. Learn More about nocturnal. Time Traveler for nocturnal The first known use of nocturnal was in the 15th century See more words from the same century.
This short article about biology can be made longer. You can help Wikipedia by adding to it. Category : Sleep. In Judaism, the Tikkun HaKlali , also known as "The General Remedy," is a set of ten Psalms designed in by Rebbe Nachman , whose recital is intended to serve as repentance for nocturnal emissions.
Saint Augustine held that male nocturnal emissions, unlike masturbation , did not pollute the conscience of a man, because they were not voluntary carnal acts, and were therefore not to be considered a sin. Moreover, whereas a person fasting in Ramadan or otherwise would normally be considered to have broken their fast by ejaculating on purpose during either masturbation or intercourse , nocturnal emission is not such a cause.
They are still required to bathe prior to undergoing some rituals in the religion. Muslim scholars consider ejaculation something that makes one temporarily ritually impure, a condition known as junub ; meaning that a Muslim who has had an orgasm or ejaculated must have a ghusl consisting of ablution followed by bathing the entire body so that not a single hair remains dry on the whole body — may also require one to rub the body according to Maliki school of thought , dalk in Arabic — while showering before they can read any verse of the Qur'an or perform the formal prayers.
Informal supplications and prayers du'a do not require such a bath. In European folklore, nocturnal emissions were believed to be caused by a succubus copulating with the individual at night, an event associated with sleep paralysis and possibly night terrors. From Wikipedia, the free encyclopedia. This article is about the biological function. For the sound art group, see Nocturnal Emissions. For the condition of excessive, accidental ejaculation, see spermatorrhea.
For other uses, see Wet dream disambiguation. Physiological responses to dreamed sexual activity during lucid REM sleep. Psychophysiology, 20, This section needs additional citations for verification. Thank you. Glad you had a good journey. Thank you, Gina. Glad you liked that line. Nice sound and sense in those last two lines. Leave a Reply Cancel reply Enter your comment here1. Lai S, Venugopal P, Leslie W. Long-term remission of paroxysmal nocturnal hemoglobinuria following chemoimmunotherapy for non-Hodgkin lymphoma. Clin Adv Hematol Oncol. ; 2. Rosse WF. Paroxysmal nocturnal hemoglobinuria as a molecular disease. Medicine (Baltimore). ; 3.